氧化平衡得分与血清尿酸和高尿血症之间的关联:来自NHANES (2011-2018) 的基于人口的研究
Yuhao Yang1, Zengxiang Wu1, Zhenmei An2
1General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in endocrinology
|July 5, 2024
概括
通过氧化平衡得分 (OBS) 测量较高的抗氧化剂暴露与较低的血清尿酸水平和美国成年人中减少的超尿血症风险有关. 这表明OBS可能在预防高尿路血症方面发挥作用.
科学领域:
- 营养科学 营养科学
- 生物化学 生化学
- 公共卫生 公共卫生
背景情况:
- 氧化应激会影响整体健康.
- 氧化平衡评分 (OBS) 量化了抗氧化剂和氧化剂的暴露.
- 需要研究OBS,血清尿酸 (SUA) 和高尿血的关系.
研究的目的:
- 为了检查氧化平衡得分 (OBS) 和血清尿酸 (SUA) 水平之间的关联.
- 调查OBS与美国成年人高尿路血的患病率之间的相关性.
主要方法:
- 利用了2011-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 基于16种营养素和4种生活方式因素 (抗氧化剂和亲氧化剂) 计算的OBS.
- 在15,096名成年人样本上使用多变量逻辑回归分析.
主要成果:
- 较高的OBS与较低的SUA水平有显著的关联 (β=-16.94在lnOBS中每单位增加).
- 增加的OBS量位与降低的高尿血的患病率相关 (OR=0.62最高四分位数).
- 在OBS和SUA之间观察到显著的性别依赖相互作用 (p<0.05).
结论:
- 在美国成年人中,OBS和SUA水平/高尿素血的患病率之间存在负相关性.
- 研究结果表明,OBS可能为hyperuricemia预防策略提供见解.
- 需要进一步的大规模前性研究来证实OBS在高尿血症中的作用.
更多相关视频
06:19Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
Published on: May 12, 2020
28.6K
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
214
相关概念视频
02:45Calculating pH Changes in a Buffer Solution
A buffer can prevent a sudden drop or increase in the pH of a solution after the addition of a strong acid or base up to its buffering capacity; however, such addition of a strong acid or base does result in the slight pH change of the solution. The small pH change can be calculated by determining the resulting change in the concentration of buffer components, i.e., a weak acid and its conjugate base or vice versa. The concentrations obtained using these stoichiometric calculations can be used...
01:31pH Homeostasis
Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory Regulation of...
Respiratory Regulation of...
01:17Hormonal Regulation of Blood Pressure
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
01:25Acid-Base Balance
The human body maintains a narrow pH range regulated through acid-base balance. This balance is crucial as changes in the hydrogen ion concentration can disrupt cell membrane stability, alter protein structures, and change enzyme activities. The normal pH of arterial blood is 7.4, venous blood and interstitial fluid is 7.35, and intracellular fluid averages 7.0.
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
01:29Renal Regulation of Acid-Base Balance
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
01:29Disorders of Acid-Base Balance
The human body maintains a precise pH range of arterial blood between 7.35 and 7.45. Deviations result in either acidosis (pH < 7.35) or alkalosis (pH > 7.45). These conditions are further classified as respiratory or metabolic disorders based on their underlying cause.
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...