双向压力:对呼吸机 - 肺 - 脏相互作用的小审查
Avnee Kumar1,2, Katie Epler1,2, Sean DeWolf1,2
1VA San Diego Healthcare System, San Diego, CA, United States.
Frontiers in physiology
|July 5, 2024
概括
机械通风可以通过影响 perfusion 和激活有害通路,导致急性损伤 (AKI). 了解这些呼吸机-肺-相互作用对于改善重症监护结果和开发新治疗方法至关重要.
科学领域:
- 关键护理医学 关键护理医学
- 腎臟病學 (nephrology) 是一種醫學.
- 肺部病理学 肺部病理学
背景情况:
- 急性损伤 (AKI) 和需要机械通风的呼吸衰竭在危急疾病中很常见.
- 一个器官系统的故障会增加另一个器官系统的故障风险,导致同时发生高频率的AKI和机械通风.
- 这种组合显著恶化了重症监护室的结果,包括死亡率.
研究的目的:
- 审查目前对机械通风引起的AKI机制的理解.
- 探索AKI如何增加呼吸衰竭的风险.
- 总结目前的治疗策略,以预防重症患者的肺和损伤.
主要方法:
- 审查有关呼吸机-肺-脏相互作用的现有文献.
- 讨论包括输液,神经激素通路和炎症调解剂在内的机制.
- 目前临床管理方法的总结.
主要成果:
- 机械通风影响 perfusion 和激活神经激素通路.
- 阳性压力通风和通风器诱导的肺损伤释放影响的炎症媒介.
- AKI会加剧呼吸系统衰竭的风险.
结论:
- 关于呼吸机-肺-脏相互作用的知识缺口仍然存在.
- 目前的治疗方法主要是支持性.
- 需要进一步的研究来开发新的治疗策略.
相关概念视频
Physiological Control of Respiration
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Regulation of Ventilation
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Mechanical Ventilation II: Invasive Ventilation
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Noninvasive Positive-Pressure Ventilation (NIPPV)
Noninvasive Positive-Pressure Ventilation (NIPPV)
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There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...


