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铜/继电器催化使得具有立体分离的1.6倍奇拉诱导成为可能

Hao-Ran Yang¹, Xiang Cheng¹, Xin Chang¹

¹College of Chemistry and Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, Wuhan University Wuhan Hubei 430072 P. R. China xiuqindong@whu.edu.cn cjwang@whu.edu.cn.

Chemical science

|July 5, 2024

概括

这项研究引入了一种新的双催化方法,用于用远程立体中心合成奇拉化合物. 这种方法有效地产生了有价值的氨基和衍生物的所有立体异构体.

科学领域:

有机化学有机化学
催化剂是一种催化剂.
立体选择性合成立体选择性合成

背景情况:

双催化能够从相同的原料中合成异构体的立体分离合成.
用两个遥远的,不连续的立体中心合成化合物具有挑战性和不发达.
的 ζ-基氨基衍生物在合成上是有用的,并且具有生物学意义.

研究的目的:

开发一种用于合性 ζ-基氨基衍生物的立体分离合成,具有远程的1,6-非连续立体中心.
为了实现与三个远程立体中心的性产品所有八种立体同位素的立体分离合成.

主要方法:

使用了一种级协议,涉及脱,1,6-迈克尔添加和化.
双金属铜/继电催化被用于转化.
控制立体化学的奇拉铜和催化剂的直角变换.

主要成果:

该协议成功地用远程的1,6-非连续立体中心合成了性 ζ-基氨基衍生物.
目标氨基的所有四个立体同位素均易于获得.
性产品的所有八种立体异构体都得到了优秀的合成结果.

结论:

开发的双催化策略为复杂的性分子提供了一个高效和原子经济的途径.
这种方法可以访问有价值的氨基和衍生物的所有立体异构体.
这种方法突显了双金属中继催化在立体选择性合成中的力量.

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