饮食模式和结核病药物诱导肝损伤的风险:一个队列研究
Jinyu Wang1, Yarui Zhou1, Cong Zhao1
1School of Public Health, Institute of Nutrition and Health, Qingdao University, Qingdao, China.
Frontiers in nutrition
|July 5, 2024
概括
通过中国健康饮食指数 (CHDI) 衡量健康饮食,可以预防结核病药物诱导的肝损伤. 相反,高含器官肉,家禽和植物油的饮食会增加肝损伤的风险.
科学领域:
- 营养和肝病学 营养和肝病学
- 结核病治疗并发症 结核病治疗并发症
- 饮食模式分析饮食模式分析
背景情况:
- 营养在结核病药物诱导性肝损伤 (TBLI) 中起作用.
- 饮食模式和TBLI风险之间的具体关系尚不清楚.
- 了解这些饮食影响对于治疗结核病患者的TBLI至关重要.
研究的目的:
- 调查饮食模式与发展结核病药物诱导肝损伤的风险之间的关联.
- 确定特定的饮食成分,这些成分可能会保护或有助于TBLI.
- 为肺结核患者提供基于证据的饮食建议,这些患者有肝损伤的风险.
主要方法:
- 在中国 (2011-2013) 进行了一项涉及605名结核病患者的队列研究.
- 在结核病治疗期间,使用半定量食物频率调查问卷来评估饮食摄入量.
- 中国健康饮食指数 (CHDI) 被用作先验饮食模式,并使用主要成分分析 (PCA) 确定后期模式.
主要成果:
- 较高的中国健康饮食指数 (CHDI) 评分与肝损伤和功能障碍的风险降低有关 (每次SD的aOR分别为0.61和0.47).
- 由"器官肉,家禽和植物油"为特征的饮食模式与肝损伤和功能障碍的风险增加有关 (aOR:分别为3.02和1.83).
结论:
- 一个高的CHDI得分作为一种保护因素,防止结核病药物诱导的肝损伤.
- 富含器官肉,家禽和植物油,低含蔬菜的饮食模式是TBLI的独立风险因素.
- 饮食修改可能是减轻结核病患者TBLI风险的可行策略.
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