在生命早期遭受饥荒的暴露增加了老年阶段白内障的风险
Jiayuan Feng1,2, Hui Niu1,2, Sijing Zhu1
1Department of Obstetrics and Gynecology, Maternal and Child Health Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Frontiers in nutrition
|July 5, 2024
概括
早期的饥饿暴露显著增加了晚年白内障的风险,特别是在女性身上. 解决儿童营养缺陷对于预防与年龄相关的视力丧失至关重要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 老年学是一门学科.
背景情况:
- 早期的营养缺乏与晚年疾病风险增加有关.
- 调查历史饥荒暴露的长期健康后果对于公共健康至关重要.
- 白内障是老年人视力受损的主要原因,需要对其危险因素进行研究.
研究的目的:
- 检查不同早期生活阶段的饥荒暴露与老年人患白内障的风险之间的关联.
- 为了确定饥荒暴露的时间 (童年与成年) 是否影响白内障风险.
- 探索早期饥饿和老年人白内障发展之间的关系中的潜在性别差异.
主要方法:
- 利用了2018年中国长度健康长寿调查 (CLHLS) 中5931名参与者的数据.
- 根据历史饥荒期间的年龄分类参与者:成年,学龄和青少年暴露组.
- 采用二元物流回归模型来分析饥荒暴露时间和白内障患病率之间的相关性.
主要成果:
- 无论是学龄 (OR=2.49) 和青少年 (OR=1.45) 的饥荒暴露都与与成人暴露相比,在老年时白内障的风险更高显著相关.
- 观察到一个显著的性别差异,女性经历较高的白内障风险儿童饥荒暴露后比男性.
- 这些发现强调了早期营养压力对长期眼睛健康的持久影响.
结论:
- 早期的饥饿暴露是老年人患白内障的重要危险因素.
- 针对性营养干预在关键发育时期,特别是女性,可能有助于减轻白内障风险.
- 这项研究强调了在儿童时期解决营养安全问题的重要性,以预防与年龄有关的疾病.
相关概念视频
01:22Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K
01:25Glaucoma: Overview
538
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
538
01:17Accessory Structures of the Eye
1.5K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.5K