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急性至慢性肝衰竭的预测结果:叙述性审查

Nitish Batra¹, Shilpa A Gaidhane¹, Sunil Kumar¹

¹Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

|July 5, 2024

概括

急性至慢性肝衰竭 (ACLF) 具有显著的死亡风险. 本综述阐明了与乙型肝炎病毒相关的ACLF的定义,诊断和治疗,强调肝移植是最佳治疗方法.

科学领域:

肝病学肝病学是一种肝病学.
胃肠病学胃肠病学
内部医学内部医学

背景情况:

急性至慢性肝衰竭 (ACLF) 是慢性肝病的严重并发症,其特征是急性肝损伤和肝外器官衰竭.
它导致短期死亡率增加,并对临床医生提出重大挑战,因为定义和临床表现各不相同.
乙型肝炎病毒 (HBV) 感染是ACLF的常见原因,特别是在底层肝硬化患者中.

研究的目的:

提供关于HBV相关ACLF的定义,诊断,流行病学,病因学,治疗和预后的全面审查.
根据当前的流行病学和临床研究,更新对HBV-ACLF的理解.
强调HBV-ACLF的最佳治疗策略.

主要方法:

对与HBV相关的ACLF的流行病学和临床研究进行系统审查和综合.
对诊断标准,患者人口统计和病因因素的现有数据的分析.
评估当前的治疗干预和预后指标.

主要成果:

与HBV相关的ACLF的特点是快速进展和高短期死亡率.
肝移植 (LT) 被认为是HBV-ACLF最有效的治疗方法.
核胺类同类物和人造肝脏支持系统显示出改善特定患者生存的潜力.

结论:

准确的定义和诊断对于管理HBV-ACLF至关重要.
肝移植为HBV-ACLF患者提供了最好的生存机会.
结合抗病毒疗法和支持性护理的多学科方法对于优化结果至关重要.

关键词:

从急性肝衰竭到慢性肝衰竭.悬崖-c-aclf分数的得分最终阶段肝病 (meld) 的模型器官衰竭器官衰竭器官衰竭器官衰竭器官衰竭器官预后标志物预后标志物

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