肝硬化患者虚弱的预测因素
Muhammad Qaiser Panezai1, Raja Taha Yaseen1, Shoaib Ahmed Khan1
1Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, PAK.
Cureus
|July 5, 2024
概括
肝硬化中的脆弱性是由女性的性别,年龄较大,高中性粒细胞,低血红蛋白和严重的肝功能障碍预测的. 这些因素增加了晚期肝病患者的脱补偿和住院风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
- 内部医学 内部医学
背景情况:
- 脆弱性在晚期肝病中普遍存在,增加了脱补偿,住院和移植列表的删除.
- 识别虚弱预测因子对于管理肝硬化患者和优化移植候选人至关重要.
研究的目的:
- 确定肝硬化患者虚弱的独立预测因子.
- 了解导致晚期肝病虚弱的因素.
主要方法:
- 132名肝硬化患者 (18-70岁) 的横截面研究,不包括心肺病和HCC.
- 肝脏脆弱指数 (LFI) 通过手握强度,定时椅站和平衡测试 (LFI>4.5被认为是脆弱) 来测量.
- 统计分析包括单变量和多变量分析 (p<0.05显著).
主要成果:
- 38.6%的患者是脆弱的.
- 单变量分析显示了脆弱性和女性性别,晚年,白细胞/中性粒细胞升高,肌素/胆红素/原血时间升高,儿童特考特普高 (CTP) 和MELD得分高,以及低血红蛋白/白蛋白之间的关联.
- 多变量分析确定了女性性别,年龄>40,CTP>B7,血红蛋白<10g/dl,中性粒细胞>60%作为独立预测因素.
结论:
- 女性性别,晚年,中性粒细胞增加,血红蛋白降低和肝脏功能障碍增加是肝硬化患者虚弱的独立预测因素.
- 这些发现有助于识别针对性干预的高风险患者.
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