与可卡因使用有关的结构性大脑变化和可卡因使用障碍治疗中的数字认知行为疗法
Li Yan McCurdy1,2, Elise E DeVito1, Jennifer M Loya1
1Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA.
Drug and alcohol dependence reports
|July 5, 2024
概括
大脑成像显示在治疗期间可卡因使用障碍 (CUD) 患者的结构变化. 尾状体和小脑的灰质体积减少与可卡因使用相关,而更多的基于计算机的认知行为疗法 (CBT4CBT) 与状圈的变化有关.
科学领域:
- 神经成像是一种神经成像.
- 成精神病学成精神病学
- 神经科学是一个神经科学.
背景情况:
- 有限的研究存在于可卡因使用障碍 (CUD) 恢复期间的大脑变化.
- 很少有研究将特定的CUD治疗与可观察到的脑部变化联系起来,阻碍了治疗优化.
- 了解这些变化可以指导开发更有效的CUD干预措施.
研究的目的:
- 在接受治疗的CUD患者中研究大脑结构的纵向变化.
- 探索特定治疗组件 (CBT4CBT,胺胺) 与大脑结构修改之间的关系.
- 为了确定潜在的神经生物学机制,在CUD治疗反应的基础上.
主要方法:
- 从41名在基线和12周门诊治疗后患有CUD的个人收集了长度T1加权的MRI扫描.
- 参与者是随机对照试验的一部分,接受基于计算机的认知行为疗法 (CBT4CBT) 和胺或安慰剂.
- 基于全脑素的形态测量和感兴趣区域的分析被用来评估灰质体积 (GMV) 的变化.
主要成果:
- 从基线到治疗后,无论治疗条件如何,在右尾状体,双边小脑和右中叶圈中观察到灰质体积 (GMV) 的显著减少.
- 右尾状和小脑转基因病毒的较大减少与治疗期间更高的可卡因使用水平有关.
- 增加对CBT4CBT模块的参与与右中旋中更大的GMV减少相关.
结论:
- 这项研究提供了与参与数字认知行为治疗成 (CBT4CBT) 相关的结构性大脑变化的第一个证据.
- 这些发现支持先前关于与可卡因使用相关的尾状和小脑转基因病毒变化的研究.
- 这些结果表明,CBT4CBT可能通过改变参与语义知识处理的大脑区域来影响物质使用行为.
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