患有甲基慢性逆侧乳腺癌的患者的生存分析:从回顾性研究的见解
Byeong-Kwan Park1, Jean Schneider2, Young Jin Suh1
1Division of Breast and Thyroid Surgical Oncology, Department of Surgery, The Catholic University of Korea St. Vincent's Hospital, Suwon, Gyeonggi 16247, Republic of Korea.
Oncology letters
|July 5, 2024
概括
年龄较小,瘤的攻击性特征和三阴性乳腺癌 (BC) 会增加患甲基慢性逆侧BC的风险. 考虑到这些风险因素,长期监测对BC幸存者至关重要.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 乳腺癌 (BC) 治疗的进步增加了幸存者的数量.
- 在BC幸存者中,甲基慢性逆侧乳腺癌 (MCBC) 发病率上升.
- 影响MCBC发展的因素需要进一步调查.
研究的目的:
- 为了确定甲时慢性逆侧乳腺癌 (MCBC) 发展的风险因素.
- 为了评估最初的ipsilateral乳腺癌 (IBC) 横向性对MCBC风险的影响.
- 为乳腺癌幸存者的长期监测策略提供信息.
主要方法:
- 从韩国乳腺癌登记处 (1989-2013) 追溯分析了17082名0-3期IBC患者.
- 患有MCBC (n=88) 和没有MCBC (n=16,994) 的患者之间的风险因素比较.
- 用于风险评估的细灰分布危险模型.
主要成果:
- 年龄较小 (<40岁),组织学/核学等级高 (3),三阴性BC与较高的MCBC风险有关.
- 随着时间的推移,MCBC的累积发病率增加,到第10年达到1.6%.
- 预测MCBC的预测因素包括年龄<40,阴性孕激素受体和Ki-67>14%.
结论:
- 年龄<40岁,阴性孕激素受体状态和高Ki-67是MCBC的关键预测因素.
- 识别这些风险因素有助于针对乳腺癌幸存者的长期监测.
- 对MCBC病因和预防的进一步研究是有必要的.
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