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粘膜头部和部癌症的组织病理特征粘膜头部和部癌症的组织病理特征粘膜头部和部癌症

Alexander J Jones¹, Leah J Novinger², Andrea Bonetto²

¹Indiana University School of Medicine Department of Otolaryngology-Head & Neck Surgery, Indianapolis, IN, USA.

International journal of surgical oncology

|July 5, 2024

概括

头癌 (HNC) 缓解症与具有结节转移的更大,更具侵入性的瘤有关. 侵袭性组织学特征显著导致这些患者的缓解症严重程度.

科学领域:

在瘤学瘤学.
病理学病理学病理学
癌症研究癌症研究

背景情况:

卡切西亚显著影响头癌 (HNC) 患者.
了解阴道病理学相关的缓解症对于患者的管理至关重要.

研究的目的:

为了确定与HPV阴性粘膜状细胞癌的空气消化道的缓解症严重程度相关的组织病理特征.

主要方法:

对222名接受切除和重建的HNC患者的回顾性分析.
收集的数据包括人口统计,并发症,营养和外科病理.
在患有和没有严重缓冲症的患者之间比较了他的病理特征.

主要成果:

在57.2%的患者中出现了白血病;18.5%的患者患有严重的白血病.
严重的缓解症与较低的血红蛋白和白蛋白,较大的瘤大小,更大的入侵深度和先进的T / N阶段相关.
多变量分析确定了瘤大小,口腔位置和节点负担是缓冲症的重要贡献者.

结论:

较大,具有结节参与和侵略性组织学特征的侵入性瘤与粘膜HNC的缓解症严重程度增加有关.
这些发现凸显了基因病理学在预测和管理HNC. cachexia中的重要性.

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