与IgG4相关的疾病具有类似于鼻恶性瘤的表现
Xijun Lin1, Peiliang Lin1, Jianming Fan2
1Department of Otolaryngology-Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Frontiers in immunology
|July 5, 2024
概括
侵袭性IgG4相关疾病 (IgG4-RD) 可以模仿鼻癌. 使用血清IgG4水平的早期诊断对于预防器官损伤至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 免疫球蛋白G4相关疾病 (IgG4-RD) 呈现为器官质量,通常模仿炎症和恶性疾病.
- 具有侵略性的IgG4-RD可以呈现与鼻癌相似的症状,这给诊断带来了挑战.
研究的目的:
- 要突出四个IgG4相关疾病的病例,具有模仿鼻癌的侵略性表现.
- 提供有关IgG4相关疾病诊断的见解.
主要方法:
- 对四名被诊断患有IgG4相关疾病的患者的病例系列审查.
- 针对IgG4阳性血细胞的免疫组织化学分析.
- 对血清IgG4水平的测量.
主要成果:
- 53-64岁的患者,病期为4-6个月,出现头痛,鼻或双眼视.
- 所有患者的IgG4+血细胞/HPF>10个,血清IgG4水平升高 (218-765毫克/分升).
- 所有病例都符合IgG4-RD的诊断标准.
结论:
- IgG4-RD的临床表现可能与鼻癌非常相似.
- 虽然病理学是确定的,但血清IgG4水平有助于诊断.
- 及时诊断IgG4-RD至关重要,以避免活跃疾病中的二次器官损伤.
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