滴到门 鼻子滴减轻败血症引起的认知功能障碍
Yaping Zhuang1, Xiyu Du2, Li Yang3
1Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Huangpu, Shanghai, 200025, P. R. China.
Small (Weinheim an der Bergstrasse, Germany)
|July 5, 2024
概括
一种新的鼻滴系统 (DGND) 有效地将药物输送到大脑,绕过血脑屏障. 这种非侵入性方法通过减少神经炎症来改善败血症的认知功能.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 鼻腔药物输送提供了一条非侵入性通往中枢神经系统 (CNS) 的途径,绕过了血脑屏障.
- 开发有效的策略来提高药物度和在鼻腔中的停留时间对于中枢神经系统疾病的治疗至关重要.
- 败血症引起的认知功能障碍涉及由微质细胞介导的神经炎症.
研究的目的:
- 设计和评估一种新的Drop to Gate鼻滴 (DGND) 系统,以有效地向大脑输送药物.
- 通过针对神经炎症来研究DGND在治疗败血症引起的认知功能障碍方面的潜力.
- 通过鼻腔给药,增强药物向大脑的输送,改善中枢神经系统疾病的治疗结果.
主要方法:
- 基于热凝的DGND系统的开发,其中包括C8-GelMA和SRT1720 (SA) 纳米凝.
- 利用疏水性相互作用和紫外线交叉链接,形成对矩阵金属蛋白酶 (MMP) 反应的含药纳米凝.
- 在体外评估DGND对脂聚糖 (LPS) 诱导的BV2细胞的抗炎作用,并在毒症诱导的认知功能障碍的小鼠模型中进行体内评估.
主要成果:
- 该DGND系统成功地在鼻腔中形成了局部凝,增加了药物停留时间和输送效率.
- 实验室研究表明,DGND有效地缓解了LPS诱导的BV2炎症.
- 在体内研究表明,DGND向鼻腔粘膜,向大脑输送药物,激活Sirt1,减少微质炎症,并在败血症小鼠中改善认知缺陷.
结论:
- 该DGND系统提供了一种高效且非侵入性的策略,通过鼻腔给药将药物输送到大脑.
- 通过调节神经炎症,DGND显示出治疗中枢神经系统疾病的巨大潜力,特别是因败血症引起的认知功能障碍.
- 开发的基于热凝的纳米载体系统为增强脑药物输送和治疗干预提供了一个有前途的平台.
相关概念视频
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
118
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
118
01:30Epistaxis
144
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
144