一代单一的表观遗传变化在囚禁和强化后代在一个三角洲 (Hypomesus transpacificus) 保护化场的后代
Ensieh Habibi1, Michael R Miller1, Andrea Schreier1
1Department of Animal Science, University of California Davis, Davis, California, USA.
Molecular ecology
|July 5, 2024
概括
化实践在几代人内显著改变了危的三角洲的表观遗传学. 这些表观遗传变化,特别是DNA甲基化,受到养殖环境的强烈影响,可能会影响野生种群.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 保护生物学 保护生物学
- 水产养殖是水产养殖的一种方式.
背景情况:
- 临灭绝的三角洲 (Hypomesus transpacificus) 种群在鱼类保护和养殖实验室 (FCCL) 被关押.
- 尽管有遗传管理,但野生和化场养殖的三角洲之间存在健康差异.
- 化化可能涉及分子变化,包括表观遗传修饰.
研究的目的:
- 为了研究化化化化化化在三角洲的分子基础.
- 要量化表观遗传差异,特别是DNA甲基化模式,在野生和化场原产地三角洲 smelt.
- 评估化场环境和几代人对表观遗传特征的影响.
主要方法:
- 用全基因组双硫酸盐测序来分析DNA甲基化模式.
- 在野生 (G0) 和多代 (G1,G2,G3) 的化场养殖鱼之间进行了比较.
- 鉴定和分析了差异甲基化区域 (DMR).
主要成果:
- 在野生和化场鱼之间,DNA甲基化模式的实质性差异迅速出现.
- 在化场养的鱼类中观察到高甲基化DMR的比例较高.
- 养殖环境是甲基化模式的强大决定因素,而不是家庭,性别或世代.
结论:
- 化场环境会诱导三角洲的显著表观遗传变化,即使是在早期的世代.
- 表观遗传特征在被囚禁的连续几代人中得到加强.
- 这些表观遗传变化可能对野生三角洲矿种群的保护产生长期影响.
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