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基因组甲基转移酶G9a通过调节NFATc1功能来抑制骨质细胞生成和骨质再吸收

Koichiro Komatsu1, Hisashi Ideno1, Kazuhisa Nakashima1

  • 1Department of Pharmacology, Tsurumi University School of Dental Medicine, Yokohama, Japan.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|July 5, 2024
PubMed
概括

表观遗传修饰剂G9a (EHMT2) 通常会抑制骨质细胞的形成. 在细胞和小鼠中删除G9a会增加骨质细胞活性和骨质损失,这表明G9a是治疗骨疾病的目标.

关键词:
骨发育 骨的发育 骨的发展骨质再吸收 骨质再吸收细胞分化的细胞分化.甲基转移酶是一种甲基转移酶.骨质结晶体的骨质细胞.

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