基于醇和氨酸的杀菌剂 (2014-2023) 的设计和开发的最新进展 (2014-2023)
Ebrahim Saeedian Moghadam1, Fahimeh Bonyasi2, Bahareh Bayati2
1Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran 1417614411, Iran.
Journal of agricultural and food chemistry
|July 5, 2024
概括
菌病威胁着农业,需要新的杀菌剂. 本综述根据环形大小对含的醇和氨酸杀菌剂进行了分类,以帮助作物保护研究.
科学领域:
- 农业科学 农业科学
- 药用化学 医学化学
- 有机化学 有机化学
背景情况:
- 真菌病对全球农业生产和粮食安全构成重大威胁.
- 发展对现有杀菌剂的耐药性需要发现用于作物保护的新生物活性剂.
- 含的异环化合物,特别是醇和酶,是现代真菌杀菌剂开发中的关键药.
研究的目的:
- 提供含的醇和氨酸杀菌剂的全面,分类审查.
- 组织和总结已发表的关于这些异环基支架的杀菌活动的研究.
- 通过根据环形大小对分子进行分类,促进在杀菌剂发现中识别新的化合物.
主要方法:
- 对有关具有杀菌活性的醇和氨酸衍生物的已发表文章的系统文献综述.
- 合成分子的分类基于含的异环环的尺寸 (醇和氨酸家族).
- 报告的杀菌活性和结构-活性关系的分析.
主要成果:
- 鉴定和分类了一系列基于醇 (imidazole,pyrazole) 和氨酸 (pyrimidine,pyridazine,pyrazine) 架构的合成杀菌剂.
- 强调了这些含异环作为有效杀菌剂的核心结构的重要性.
- 在过去十年中,使用这些环系统的杀菌剂的发展趋势显示出了趋势.
结论:
- 含的醇和氨酸衍生物是合成杀菌剂的重要类别.
- 这种基于环大小的分类为作物保护研究人员提供了宝贵的资源.
- 进一步探索这些支架有望开发下一代杀菌剂来对抗作物疾病.
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