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肠道微生物群-lncRNA/circRNA交叉:对不同疾病的影响
Lei Zhang1, Xin Li1, Huijuan Gao1
1Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Critical reviews in microbiology
|July 5, 2024
概括
肠道微生物群与长非编码RNAs (lncRNAs) 和循环RNAs (circRNAs) 相互作用,影响结直肠癌和精神健康状况等疾病. 这种交叉交流为新的疾病预防和治疗策略提供了潜力.
科学领域:
- 微生物学 微生物学
- 分子生物学分子生物学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 肠道微生物群对于人类生理学和代谢平衡至关重要.
- 微生物失衡 (失生症) 与各种疾病有关.
- 长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs) 是细胞过程中的关键调节者.
研究的目的:
- 审查肠道微生物群与lncRNAs/circRNAs之间的相互作用.
- 为了研究这种交叉在疾病发病过程中的作用.
- 为了强调这种相互作用的临床价值.
主要方法:
- 对肠道微生物群,lncRNAs和circRNAs现有研究的文献综述.
- 分析详细介绍相关监管机制的研究.
- 综合与疾病发展和进展相关的发现.
主要成果:
- 肠道微生物群针对特定的 lncRNA (例如,ENO1-IT1,BFAL1,LINC00152) 来调节结直肠癌.
- 肠道微生物群调节circRNAs (例如circNF1-419,circHIPK2),影响精神疾病和肺瘤转移.
- 有证据支持微生物群-RNA交叉在各种病理中发挥着重要作用.
结论:
- 肠道微生物群与lncRNAs/circRNAs之间的相互作用是疾病发展的关键因素.
- 了解这种交叉通话为新的治疗方法提供了理论基础.
- 针对肠道微生物群-lncRNA/circRNA轴具有显著的临床潜力.
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