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在怀孕期间监测甲状腺功能,对甲状腺自身免疫的无甲状腺妇女进行监测
Aglaia Kyrilli1, Bernard Corvilain1, Sofie Bliddal2,3
1Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.) - Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Endocrine connections
|July 5, 2024
概括
孕妇甲状腺自身免疫很少导致生物化学进展. 对于TPOAb+女性,建议监测甲状腺功能,尽管基线TSH较高是进展的主要风险因素.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺自身免疫 (TAI) 影响1至17%的孕妇.
- 建议对带有抗甲状腺氧化酶抗体 (TPOAb+) 的孕妇进行甲状腺功能监测.
研究的目的:
- 为了确定生化进展 (血清TSH>2.5mU/L) 在euthyroid孕妇的患病率.
- 根据TPOAb状态确定生物化学进展的临床和生物风险因素.
主要方法:
- 来自两个单独怀孕妇女队伍 (n=340) 的人口统计和生物数据的分析.
- 包括怀孕期间至少有两个TSH和FT4测量和一个TPOAb测量的妇女.
- 在第二次采血时对TSH水平的评估,相对于最初的TPOAb状态.
主要成果:
- 少数女性 (4.2%) 经历了生化进展,TPOAb+女性 (9.4%) 与TPOAb-女性 (2.7%) 明显更常见.
- 在第二次采样中,没有发现TSH>4mU/L的病例.
- 较高的TSH基线水平与TPOAb+和TPOAb-组的生物化学进展有关.
结论:
- 甲状腺功能的生物化学进展在甲状腺自身免疫的孕妇中很少发生.
- 需要进行更大规模的研究,以确定在怀孕期间从密集的甲状腺功能监测中获益最多的妇女的特定子组.
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