姆波克斯角膜炎:一个病例报告和综述
Christopher R Croasdale1, Eric Weinlander2, Thomas G Boyce3
1SSM Health, Davis Duehr Dean Clinic, Madison, WI.
Cornea
|July 5, 2024
概括
姆波克斯角膜炎是一种罕见但严重的眼睛疾病. 早期诊断和tecovirimat治疗可以改善结果,尽管可能出现严重的视力丧失. 本综述强调了眼科专业人员的关键发现.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 马波克斯 (Mopox) 是一种病毒性疾病,具有潜在的眼部表现.
- 角膜感染的Mpox角膜炎是很少诊断的,这阻碍了有效的患者管理.
- 眼科专业人员的有限认识有助于诊断挑战.
研究的目的:
- 提高眼科专业人员对mopox角膜炎的了解.
- 审查mopox角质炎的临床表现,诊断和管理.
- 报告一个成功的角膜移植mopox角膜炎的独特案例.
主要方法:
- 一项系统的文献搜索从1970年到2024年确定了35例mopox角膜炎病例.
- 对病例报告和摘要进行分析,以确定病例发生频率,临床特征和结果.
- 包含一个涉及穿透角膜整形术的案例研究,随访20年.
主要成果:
- 莫波克斯角质炎发生在0.5%~1.0%的有症状的莫波克斯患者中,有或没有全身性疾病.
- 最初的错误诊断很常见 (40%);聚合酶链反应 (PCR) 有助于诊断.
- 角质干扰从轻度到重度不等;结果从良好的视力到失明.
- 在大多数情况下,Tecovirimat在没有 fulminant 系统性疾病的情况下显示出有效性.
- 据报道,在一个独特的案例中,成功的穿透式角质形成术.
结论:
- 虽然很少见,但Mopox角膜炎会导致明显的视力损伤和失明.
- 系统性tecovirimat似乎有效的mopox角质炎,但低发病率限制临床试验.
- 局部类固醇可能会延长角膜中的病毒存在.
- 对于确认角膜mopox感染,PCR非常有价值.
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