维生素D补充剂,血清25(OH) D度和死亡风险之间的关联:使用NHANES 2007-2018数据的前性队列研究
1Department of Pharmacy, Peking University Cancer Hospital and Institute, Beijing, China.
Therapeutic drug monitoring
|July 5, 2024
概括
较高的维生素D水平与较低的整体死亡风险有关. 虽然体内维生素补充剂剂量没有显示任何效果,但足够的血清25-基维生素D (25[OH]D) 对长寿至关重要.
科学领域:
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
- 老年学是指老年学的学科.
背景情况:
- 研究维生素D (VD) 补充,血清25-氧维生素D (25[OH]D) 水平和死亡风险之间的关系.
- 检查与所有原因和特定原因死亡率的关联.
研究的目的:
- 为了确定自我报告的维生素D补充剂之间的关联,测量血清25-基维生素D度,以及全因和因特定死亡风险.
主要方法:
- 在国家健康和营养检查调查 (2007-2018) 中,分析了来自10793名美国成年人 (≥20岁) 的数据.
- 利用考克斯回归和倾向分数匹配 (PSM) 来分析VD,25(OH) D水平和死亡率数据之间的关系,直到2019年.
主要成果:
- 较高的血清25(OH) D度 (上2个四分位数) 与较低的全因死亡率和较低的其他特定死亡率有关.
- 在VD补充剂剂量 (<800 IU/d vs. ≥800 IU/d) 和死亡风险之间没有发现显著的相关性.
- 血清25 (((OH) D水平,但不是VD补充剂,在PSM前后的统计学上有所不同.
结论:
- 较高的25(OH) D水平与所有原因和其他特定死亡率的降低密切相关,但与心血管疾病或癌症特定死亡率无关.
- 调查结果支持维持足够的VD状态,长寿,并强调公共卫生战略的重要性,以防止VD缺陷.
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