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Updated: Jun 21, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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BET odomain 抑制通过诱导细胞循环停止来增强眼睛黑色素瘤治疗的潜力

Xingyu Chen1, Rui Huang2,3, Zhe Zhang2,3

  • 1Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Investigative ophthalmology & visual science
|July 5, 2024
PubMed
概括

BRD4 抑制剂 JQ-1 通过诱导细胞循环停止,有效抑制眼球黑色素瘤的生长. 这项研究确定了潜在的治疗点和生物标志物,以改善眼球黑色素瘤患者的生存率.

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Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development06:46

Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development

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