胎儿暴露于烟草代谢物和成年期抑郁症:超越二进制测量
Edmond D Shenassa1,2,3, Jessica L Gleason1, Kathryn Hirabayashi1
1From the Department of Epidemiology and Biostatistics, Maternal & Child Health Program, School of Public Health, University of Maryland College Park, MD.
Epidemiology (Cambridge, Mass.)
|July 5, 2024
概括
怀孕期间母亲吸烟与后代抑郁症的风险和严重程度增加有关. 考虑到吸烟量和开始年龄对于理解这种联系至关重要.
科学领域:
- 生殖健康 生殖健康
- 心理健康 心理健康
- 流行病学 流行病学
背景情况:
- 怀孕期间母亲吸烟是各种不良结果的已知危险因素.
- 之前关于母亲吸烟和后代抑郁症的研究已经产生了不一致的结果.
- 吸烟的数量和开始的年龄可能会影响母亲吸烟和抑郁症之间的联系.
研究的目的:
- 调查怀孕期间母亲吸烟与后代抑郁风险和严重程度之间的联系.
- 检查吸烟量和开始年龄在这种关联中的作用.
- 为了确定怀孕期间母亲吸烟是否是抑郁症的独立风险因素.
主要方法:
- 分析了国家青年纵向调查 (1994-2016) 的数据.
- 母亲在怀孕期间报告吸烟习惯 (没有,<1包/天,≥1包/天).
- 后代抑郁症 (终身诊断和症状计数) 使用流行病学研究中心抑郁症量表进行评估;用于分析的概括线性混合效应模型.
主要成果:
- 在怀孕期间母亲吸烟与后代抑郁风险和兄弟姐妹抑郁症严重程度之间观察到剂量依赖的关联.
- 抑郁症的风险增加和严重程度与孕妇在怀孕期间吸烟的数量增加有关.
- 对于抑郁症严重程度的结果在仅限于18岁之前被诊断的后代时减弱了.
结论:
- 怀孕期间母亲吸烟独立地与抑郁症风险增加和后代抑郁症状的严重程度增加有关.
- 怀孕期间母亲吸烟的数量是抑郁症风险和严重程度的重要决定因素.
- 考虑到吸烟量和发病年龄对于全面了解母亲吸烟与后代抑郁症之间的联系至关重要.
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