在患有轻度认知障碍的患者中阻断性睡眠呼吸暂停
Dirk Schwerthöffer1,2, Tim Haselwarter1, Timo Grimmer1
1Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.
Journal of Alzheimer's disease : JAD
|July 5, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 在轻度认知障碍 (MCI) 患者中很常见,通常未被诊断出来. OSA可能会恶化认知衰退和阿尔茨海默病 (AD) 病理,需要进一步调查.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 老年学是一门学科.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与认知障碍有关,但其与轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 的患病率尚不清楚.
- 需要进一步探索OSA,认知缺陷和神经退行症之间的病理生理联系.
- 了解这些关系可以帮助认知障碍的诊断和治疗.
研究的目的:
- 为了确定OSA在MCI患者的患病率.
- 调查MCI患者与OSA的认知缺陷和AD生物标志物概况.
- 探索OSA和AD生物标志物之间的潜在关联.
主要方法:
- 呼吸道多重检查用于诊断OSA (呼吸暂停下指数).
- 神经心理测试 (CERAD NB) 用于认知评估.
- 生物标志物分析包括tau,phosphoTau181,粉样β和F18-FDG-PET.
主要成果:
- 在MCI患者中,OSA患病率高达58.7% (AHI≥5/h);25%的患者有中度至重度OSA (AHI≥15/h).
- 只有13.1%的患有OSA的MCI患者报告白天嗜睡.
- 在MCI-OSA患者中没有观察到特定的神经心理模式;OSA与AD生物标志物没有明显的关联,除了具有AD生物标志物阳性的子组.
结论:
- 在MCI患者中,OSA非常普遍,并且往往无症状,这表明频繁的诊断不足.
- OSA可能会导致MCI症状,并可能导致阿尔茨海默病的病理学.
- 需要进一步的研究来证实这些发现,并阐明将OSA与MCI和AD联系起来的病理生理机制.
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