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Updated: Jun 21, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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提升PLK1通过触发BRD4酸化依赖的降解来克服前列腺癌中的BETi耐药性

Yanquan Zhang1, Ka-Wing Fong1, Fengyi Mao2

  • 1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.

Cell reports
|July 5, 2024
PubMed
概括

含odomain的蛋白4 (BRD4) 通过PLK1依赖酸化在线分裂过程中被降解,这是前列腺癌治疗的关键机制. 这一发现有助于克服与多塞塔塞尔结合使用的BRD4抑制剂的耐药性.

关键词:
这是APC/C ((Cdh1))抗 BET 抑制剂的耐药性这就是BRD4D.CP: 癌症 癌症 癌症科普:分子生物学 分子生物学PLK1 PLK1 的意思是酸化的方法是:光化.前列腺癌是前列腺癌.

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