在LIFECODES胎儿生长研究中与胎儿生长相关的有机 Ester阻燃剂和增塑剂
Paige A Bommarito1, Danielle R Stevens1, Barrett M Welch1,2
1Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Environmental health perspectives
|July 5, 2024
概括
产前暴露于有机酸 (OPEs) 与妊娠期间更大的胎儿大小有关,但不是在分娩时. 基酸盐 (DPHP) 暴露增加了对妊娠年龄小 (SGA) 出生的风险,这表明OPE会影响胎儿发育.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 生殖健康 生殖健康
背景情况:
- 有机酸 (OPE) 在消费品中常见,作为阻燃剂和增塑剂.
- 人们怀疑OPE会导致发育性毒性.
- 了解OPE对产前发育的影响对于公共卫生至关重要.
研究的目的:
- 评估产前有机酸 (OPE) 暴露与胎儿生长之间的关联.
- 为了检查胎儿生长的超声波和分娩指标.
- 在一个潜在的队列中调查OPE的发育毒性.
主要方法:
- 在LIFECODES胎儿生长研究的孕妇参与者尿样中的量化OPE生物标志物.
- 从医疗记录中收集了胎儿生长的超声波和分娩测量.
- 使用线性混合效应模型和回归分析来估计OPE暴露与胎儿生长之间的关联.
主要成果:
- 大多数OPE生物标志物与胎儿生长的超声波测量显示出积极的关联.
- 2-乙烯酸盐暴露与更大的胎儿测量 (头部,腹部,股骨,估计体重) 有关.
- 基酸二 (DPHP) 暴露与怀孕年龄小 (SGA) 出生的风险增加有关.
结论:
- 孕期OPE暴露与怀孕期间胎儿尺寸的增加有关.
- OPE与胎儿生长之间的关联在分娩时基本上为零,除了DPHP和SGA风险.
- 研究结果表明,有机酸 Ester 可能影响胎儿发育,需要进一步调查.
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