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乌比奎丁诱导的RNF168凝结促进了DNA双链断裂修复

Li-Li Feng1,2,3,4, Shu-Ying Bie5, Zhi-Heng Deng6

  • 1Department of Pathology, Henan Provincial Key Laboratory of Radiation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Proceedings of the National Academy of Sciences of the United States of America
|July 5, 2024
PubMed
概括

在DNA双链断裂 (DSB) 时,RNF168经历液体-液体相分离 (LLPS),增强其修复功能. 这种由K63结合的多比基因引发的凝结,有助于招募像53BP1和BRCA1这样的关键修复因子,以有效修复DSB.

关键词:
DNA双链断裂修复的修复方法RNF1688 美国国家自然规则本质上是无序的区域.液体液体相分离器 液体相分离器聚尤比奎廷是一种多元化药物.

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