成人神经发生是前脑神经回路功能再生所必需的
Eliot A Brenowitz1,2, Karin L Lent1,2, Kimberly E Miller1,2
1Department of Psychology, University of Washington, Seattle, WA 98195.
概括
成年歌鸟的新神经元对于歌曲结构和大脑活动至关重要. 阻断神经发生会影响繁殖季节的歌曲恢复,突出其在神经回路中的重要性.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 神经新生是什么意思 神经新生是什么意思
背景情况:
- 成年歌鸟在电脑脑中产生新的神经元,迁移到HVC歌曲控制区域.
- 这些新的神经元将轴突投射到骨 (RA) 的坚固核中,形成HVC-RA电路,这对于学习歌曲的产生至关重要.
研究的目的:
- 调查成人神经发生在HVC-RA电路中的功能作用.
- 为了测试这样的假设,即在成年歌鸟中产生结构良好的歌曲需要新的神经元.
主要方法:
- 输注环胺,一个神经细胞迁移抑制剂,进入雄性甘贝尔白冠的HVC.
- 阻止HVC-RA电路的季节性再生,以评估对神经发生和歌曲行为的影响.
主要成果:
- 在HVC中神经发生的减少阻止了在繁殖季节RA神经元自发电活动的正常增加.
- 抑制HVC中新神经元的结合,损害了通常在繁殖鸟类中观察到的改进的歌曲结构.
结论:
- 将新神经元纳入成年HVC对于恢复RA中的电活动和繁殖鸟类的歌唱行为至关重要.
- 歌鸟系统是研究长投影神经回路中的成年神经发生的有价值模型.
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