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Updated: May 1, 2026

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一个基于活动的双重传感和标记策略揭示了抗氧化剂反应元素调节不稳定的铁池

Aidan T Pezacki1, Ryan L Gonciarz2, Toshitaka Okamura1

  • 1Department of Chemistry, University of California, Berkeley, CA 94720.

Proceedings of the National Academy of Sciences of the United States of America
|July 5, 2024
PubMed
概括

研究人员开发了一种新的光探针,铁绿-1甲基 (IG1-FM),以对活细胞中的不稳定铁池进行成像. 这种探测器揭示了铁代谢如何扩大和抗氧化反应元素 (NRF2-AREs) 耗尽铁,影响癌细胞活力.

关键词:
基于活动的传感.抗氧化剂的调节癌症的代谢 癌症的代谢光铁探针探测器是什么意思过渡金属信号传输系统

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Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
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