相关实验视频

Updated: Aug 8, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

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单细胞基因组学详细介绍了BCP-ALL中的成熟区块,并确定了DUX4-r病例中的治疗漏洞

Hanna Thorsson1, Rasmus Henningsson1, Noelia Puente-Moncada1

  • 1Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.

Blood
|July 5, 2024
PubMed
概括

这项研究使用单细胞测序揭示了儿童B细胞急性淋巴细胞白血病 (BCP-ALL) 亚型的独特细胞特征. DUX4重新排列的亚型显示出独特的成熟模式和脆弱性,导致新的向治疗策略.

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相关概念视频

Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are: