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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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前列腺特异性抗原分层用于预测男性接近推查年限的晚期前列腺癌事件.

Paul Riviere1,2,3, Leah N Deshler1,2,3, Kylie M Morgan1,2,3

  • 1Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California.

The Journal of urology
|July 5, 2024
PubMed
概括

老年男性 (70-75岁) 的前列腺特异性抗原 (PSA) 测试可以预测转移性或致命的前列腺癌风险. 黑人男性患晚期前列腺癌的风险高于白人男性,PSA水平相似.

关键词:
非洲裔美国人.癌症查 癌症查老年保健服务 老年保健服务前列腺癌是前列腺癌.前列腺特异抗原的前列腺特异抗原.

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科学领域:

  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 在瘤学瘤学.
  • 老年医学 老年医学

背景情况:

  • 前列腺癌仍然是老年男性的重大健康问题.
  • 前列腺特异性抗原 (PSA) 测试是前列腺癌查的常见工具.
  • 了解PSA在老年人群中的预测价值对于临床决策至关重要.

研究的目的:

  • 量化各种前列腺特异性抗原 (PSA) 值对70至75岁男性发展转移性或致命前列腺癌的预测能力.
  • 评估PSA测试在这个人口群体中的积极和消极预测值.

主要方法:

  • 利用了来自美国退伍军人卫生管理局的80,706名男性的随机样本,这些男性在70-75岁之间接受了PSA测试.
  • 采用累积/动态建模来考虑竞争风险,例如死于非前列腺癌原因.
  • 在测试后的5,10年和14年分析了辨别能力,积极的预测值和负的预测值.

主要成果:

  • PSA 显示了依赖时间的预测歧视,曲线下的面积 (AUC) 值在 14 年内从 0.83 降至 0.73.
  • 基于种族,没有观察到预测能力的统计学上显著差异.
  • 与PSA值在1-8 ng/mL之间的白人患者相比,黑人患者对晚期前列腺癌的积极预测值显著更高.

结论:

  • 对于70-75岁的男性,PSA水平上升到边界水平,患转移性或致命前列腺癌的风险是可量化的,并且通常很低.
  • 在这个年龄组中,前列腺癌的风险评估应考虑在黑人男性中观察到的更高发病率.
  • 这些发现有助于做出有关停止老年男性PSA检测的明智决定.