高强度聚焦超声波除结合免疫疗法治疗肝转移:一个前性的非随机试验
Xiyue Yang1,2,3, Yao Liao2,3, Lingli Fan1,2,3
1Department of Oncology, Mianyang Central Hospital, Mianyang, China.
PloS one
|July 5, 2024
概括
高强度聚焦超声波 (HIFU) 除与免疫疗法相结合是肝转移的安全和可行的治疗方法. 这种方法对患有晚期癌症和肝脏损伤的患者来说是有前途的.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 医疗成像医学成像
背景情况:
- 肝转移 (LM) 在晚期癌症治疗中存在独特的挑战.
- 将免疫疗法与其他疗法结合起来,对于提高疗效至关重要.
- 高强度聚焦超声波 (HIFU) 除已经显示出增强免疫反应的潜力.
研究的目的:
- 预期评估HIFU切除与全身免疫治疗相结合的安全性和临床可行性.
- 评估这种结合方法在肝转移患者中的疗效.
主要方法:
- 14名肝转移患者接受了超声导向的HIFU切除和免疫检查点抑制剂 (ICI),如抗编程细胞死亡蛋白1 (anti-PD-1).
- 使用常用术语对不良事件的标准 (CTCAE) v5.0.0.监测不良事件.
- 瘤反应通过计算机断层扫描进行评估.
主要成果:
- 这项研究包括14名患者 (35-84岁),他们在19个转移部位接受HIFU切除.
- 平均治疗的损伤体积为179.9厘米3 (范围高达733.1厘米3).
- 随访时间中位数为9个月 (范围为3-21个月),治疗被认为是临床可行的和可接受的.
结论:
- 与全身免疫疗法结合的HIFU切除在临床上是可行的,并且对于治疗肝转移是安全的.
- 这种联合治疗策略为患有晚期癌症和肝脏损伤的患者提供了可行的选择.
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