治疗后马胃综合征 (EGUS) 唾液分析物的变化:试点研究
Alberto Muñoz-Prieto1, Eva Llamas-Amor1, José Joaquín Cerón1
1Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo s/n, 30100 Murcia, Spain.
Research in veterinary science
|July 5, 2024
概括
唾液生物标志物如二碳酸盐,尿素,腺脱氨酶 (ADA) 和肌酸激酶 (CK) 可以表明治疗马胃综合征 (EGUS) 的成功. 马匹的成功治疗显示了这些唾液分析物的显著变化.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 生物化学 生化学
- 马的健康 马的健康
背景情况:
- 马胃综合征 (EGUS) 影响着高比例的马,特别是赛马.
- EGUS包括马状胃病 (ESGD) 和马腺胃病 (EGGD).
- 唾液提供了一种非侵入性的方法来识别马匹的潜在生物标志物.
研究的目的:
- 为了研究EGUS治疗后唾液分析物的变化.
- 识别潜在的唾液生物标志物,表明EGUS治疗成功或不成功.
- 评估自动化测试的实用性,以测量马匹患者的唾液分析物.
主要方法:
- 28匹被诊断患有EGUS的马被用梅治疗了6周.
- 在治疗前和治疗后收集唾液样本.
- 使用自动化工分析仪测量各种唾液分析物,包括酶,代谢物,蛋白质,氧化还原生物标志物和矿物质.
主要成果:
- 成功接受EGUS治疗的马的唾液二碳酸盐和尿素水平显著增加.
- 成功的治疗也与唾液腺氨酸脱氨酶 (ADA) 和肌酸酶 (CK) 的显著降低相关.
- 没有成功治疗的马在这些唾液分析物中没有显著变化.
结论:
- 唾液碳酸盐,尿素,ADA和CK显示出作为监测马匹EGUS治疗疗效的可访问生物标志物的潜力.
- 这些分析物可以快速轻松地测量,这表明了常规临床应用的潜力.
- 建议对较大的马群进行进一步的研究,以验证这些发现.
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