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Updated: Jun 21, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
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Published on: January 29, 2019

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U-PRO-CRM:设计以患者为中心的剂量确定试验,患者报告结果

E Alger1, S M Lee2, Y K Cheung2

  • 1Clinical Trial and Statistics Unit, Institute of Cancer Research, London, UK.

ESMO open
|July 5, 2024
PubMed
概括

一种新的临床试验方法,Utility-PRO-Continual Reassessment Method (U-PRO-CRM),使用患者和临床医生报告的毒性来找到最佳的癌症药物剂量. 这种方法可以提高确定最大耐受剂量 (MTD) 的准确性,同时最大限度地减少患者过量服用.

关键词:
持续重新评估的方法.确定剂量的方法.最大的耐受剂量.患者报告的结果.第一个阶段I阶段.

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