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呼吸测试中的甲气与非酒精性脂肪肝疾病有关
Sanggwon An1,2, Eui-Young Cho3, Junho Hwang1
1Department of Materials Science and Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Journal of breath research
|July 5, 2024
概括
通过呼吸测试确定的呼吸甲阳性与非酒精性脂肪肝疾病 (NAFLD) 有关. 这一发现表明甲可能是诊断NAFLD的有用生物标志物.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 代谢疾病 代谢疾病
- 肺部医学 肺部医学
背景情况:
- 已知身体质量指数 (BMI),代谢疾病和呼吸测试结果之间的关联.
- 呼吸中/甲水平与代谢障碍之间的特定关系需要进一步研究.
研究的目的:
- 调查呼气气体成分与代谢障碍之间的关系.
- 探索呼吸中的/甲含量与糖尿病,失脂症,高血压和非酒精性脂肪肝疾病 (NAFLD) 等疾病之间的联系.
主要方法:
- 对441名患者的医疗记录和乳糖呼吸试验 (LBT) 数据的分析.
- 根据LBT和甲水平 (ppm) 来分组患者.
- 多变量分析以确定代谢障碍的几率比率.
主要成果:
- 72.1%的患者仅对甲呈阳性 (<20 ppm,甲≥3 ppm).
- 与和甲阳性患者相比,只有甲阳性患者的BMI和NAFLD患病率较高.
- 只有甲的阳性与NAFLD显著相关 (OR=2.002,P=0.004).
结论:
- 呼吸甲阳性与NAFLD有显著的关系.
- 增加的呼吸甲可以作为NAFLD诊断的易于测量的生物标志物.
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