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萨库比特里尔-瓦尔萨坦对与衰老有关的心脏功能障碍的影响
Marialucia Telesca1, Antonella De Angelis1, Maria Donniacuo2
1Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via Costantinopoli 16, 80138, Naples, Italy.
European journal of pharmacology
|July 5, 2024
概括
萨库比特里尔/瓦尔萨坦和瓦尔萨坦治疗减少了老年老鼠的心脏缩,但没有改善腹功能障碍或纤维化. 这两种药物都在老年心脏中部分恢复了心脏保护性氨酸- ангиотензин- алдостерон系统 (RAAS) 信号传递.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 衰老是心力衰竭 (HF) 的一个主要危险因素,特别是心力衰竭与保留射出分数 (HFpEF) 的心力衰竭.
- 目前与衰老相关的HFpEF治疗方法有限.
研究的目的:
- 调查萨库比特里尔/瓦尔萨坦和瓦尔萨坦对与衰老相关的HFpEF的实验模型的影响.
- 评估这些药物对心脏缩,纤维化,透缩功能障碍和氨酸-血管氨酸-氨酸系统 (RAAS) 信号传导的影响.
主要方法:
- 18个月大的雌性Fisher 344只老化相关HFpEF的老鼠被用sacubitril/valsartan或 valsartan治疗了12周.
- 三个月大的老鼠作为对照.
- 评估心脏结构,功能和RAAS信号使用心声回声,导管和分子分析.
主要成果:
- 萨库比特里尔/瓦尔萨坦和瓦尔萨坦都显著降低了心脏缩,通过减少肌细胞壁厚度和肌细胞横截面积来证明这一点.
- 两种治疗都没有减少心肌纤维化或改善衰老老鼠的腹功能障碍.
- 与未经治疗的老老鼠相比,这两种药物都部分恢复了心脏保护性非经典RAAS信号传递.
- 在接受治疗的老老鼠中,心肌炎症,内皮激活和氧化应激持续存在.
结论:
- 萨库比特里尔/瓦尔萨坦和瓦尔萨坦通过减弱心肌细胞大小,对与年龄相关的心脏缩产生有利影响.
- 观察到的好处可能包括向心脏保护性RAAS信号转移.
- 透支功能障碍和心脏纤维化仍然是老年心脏的重大挑战,尽管这些治疗方法仍然存在.
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