一般的外部暴露和慢性病的发展或进展:系统性审查和元分析
Kate H Liang1, Julia M T Colombijn2, Marianne C Verhaar1
1Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands.
Environmental pollution (Barking, Essex : 1987)
|July 5, 2024
概括
长期接触细颗粒物 (PM2.5) 会增加慢性病 (CKD) 的风险. 其他环境因素,如化学品和建筑环境,需要进一步研究.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 环境风险因素对慢性病 (CKD) 的影响尚未完全理解.
- 一般的外部暴露组包括各种可能影响健康的环境因素.
- 现有的文献缺乏对暴露体在CKD发展和进展中的作用的全面概述.
研究的目的:
- 系统地审查和综合有关一般外部暴露和CKD之间的关联的证据.
- 评估环境暴露对CKD发病率,进展和死亡率的影响.
- 确定关于未被充分研究的环境因素和结局的研究缺口.
主要方法:
- 对MEDLINE和EMBASE进行系统的文献搜索,用于病例控制和队列研究.
- 纳入标准:调查一般外部暴露组和CKD结果 (eGFR变化,白蛋白尿,诊断,进展,死亡率) 的研究.
- 使用纽卡斯尔-太华尺度评估偏差风险;使用随机效应模型进行的元分析.
主要成果:
- 包括66项研究,主要关注空气污染 (颗粒物,氧化) 和重金属 (,).
- 细颗粒物 (PM2.5) 暴露与慢性病发病率的增加和进展到末期病有关.
- 对其他污染物 (NO2,PM10),重金属,化学品和建筑环境因素的证据不一致或不确.
结论:
- 长时间暴露于PM2.5是CKD发病率和进展的重要风险因素.
- 空气污染和重金属是影响健康的最受研究的环境因素.
- 需要对化学物质和建筑环境因素进行进一步的高质量研究,以了解它们对CKD的影响.
相关概念视频
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