抗中性粒细胞体抗体是与类风湿性关节炎相关的间歇性肺病的独立风险因素
Honglin Xu1, Ziyan Wu1, Yang Zhao2
1Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
概括
反中性粒细胞质抗体 (ANCA) 在类风湿性关节炎相关的间歇性肺病 (RA-ILD) 中更为普遍. 在RA-ILD患者中,ANCA阳性表明炎症更高,肺功能更差.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 类风湿关节炎相关的间歇性肺病 (RA-ILD) 是类风湿关节炎 (RA) 的严重并发症.
- 抗中性粒细胞质抗体 (ANCA) 测试用于诊断各种疾病,但其在RA-ILD中的作用需要进一步阐明.
研究的目的:
- 在被诊断为RA-ILD的患者中调查ANCA的临床意义.
- 确定ANCA状态是否可以帮助分层风险并识别RA-ILD的患者.
主要方法:
- 从接受ANCA查的RA患者的临床记录的回顾性分析.
- 使用间接免疫光检测 (IIF) 和酶相关免疫吸收检测 (ELISA) 的ANCA检测.
- 临床特征和多变量逻辑回归的比较,以评估ANCA与RA中的ILD的关联.
主要成果:
- 与没有ILD的RA (19.5%) 相比,RA-ILD患者的ANCA患病率显著更高 (31.7%).
- 对ANCA阳性RA-ILD患者的炎症标志物增加,疾病活性增加和肺功能低下.
- 多变量分析证实了ANCA,特别是周核ANCA (pANCA) 与RA-ILD之间的独立关联.
结论:
- 在RA患者的风险分层中,ANCA/pANCA可能发挥作用.
- ANCA测试可以提供补充信息来识别患有ILD风险的RA患者,并可能指导进一步的研究,如HRCT.
- 这些发现凸显了ANCA在治疗RA-ILD的临床相关性.
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