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O-GlcNAc信号传递:对瘤微环境中压力诱导的适应性反应途径的影响

Yu Zhao¹, Renlong Li², Weizhen Wang²

¹Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, 710069, China.

|July 5, 2024

概括

瘤细胞通过保留的反应适应压力. O-GlcNAcylation将葡萄糖代谢与瘤进展和抵抗联系起来,在瘤微环境 (TME) 中提供了一个新的治疗点.

科学领域:

癌症生物学癌症生物学
分子瘤学分子瘤学
代谢调节代谢调节代谢调节

背景情况:

瘤微环境 (TME) 包含瘤细胞,树皮细胞,细胞外基质和信号分子,影响瘤的开始,进展和治疗耐药性.
瘤细胞遇到内源性压力,如缺氧,DNA损伤和氧化应激,触发了生存的保存适应性反应.
O-GlcNAcylation是一种后翻译性修饰,已成为将葡萄糖代谢与瘤进展联系起来的关键调节剂.

研究的目的:

审查激应诱导的适应反应途径 (SARPs),使瘤细胞在不利条件下生存.
系统地讨论O-GlcNAcylation调节的SARP在TME重塑,瘤进展和治疗耐药性的作用.
突出针对O-GlcNAcylation在癌症治疗中的治疗潜力.

主要方法:

文献综述和对瘤微环境,细胞应激反应和O-GlcNAcylation现有研究的综合.
在压力诱导的适应反应的背景下分析O-GlcNAcylation的调节机制.
讨论针对O-GlcNAcylation途径 (OGT/OGA抑制剂) 的治疗策略.

主要成果:

瘤细胞使用多种保存的适应性反应,包括代谢重编程和DNA修复,以应对内源性压力.
O-GlcNAcylation 在调节这些压力诱导的适应反应途径 (SARPs) 中发挥着关键作用.
由O-GlcNAcylation调节的SARP显著影响TME重塑,瘤生长和对治疗的抗性.

结论:

通过调节O-GlcNAc转移酶 (OGT) 或O-GlcNAcase (OGA) 活性,准O-GlcNAcylation是抑制瘤进展的有希望的策略.
在TME中干预O-GlcNAcylated蛋白质提供了一种新的治疗方法,以改善患者的预后.
对O-GlcNAcylation在癌症中的作用进行进一步的研究是有必要的,以开发有效的抗癌疗法.

关键词:

DNA复制和损伤应激压力细胞内膜网膜应激压力氧气过低是因为缺氧.免疫系统的激活代谢性压力是代谢性的压力.这是一种O-GlcNAcylation.氧化应激是一种氧化应激.压力诱导的适应反应途径 (SARPs)瘤微环境是一个微环境.

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