灰色物质的形态生物标志物用于区分暴露在的接工人和健康的成年人,由源式形态学揭示出来
Jiayu Wu1, Qiaoying Zhang1, Mingyue Ma1
1Department of Radiology, The Affiliated Xi'an Central Hospital of Xi'an Jiaotong University, Xi'an, China.
Neurotoxicology
|July 5, 2024
概括
在接工人中,慢性 (Mn) 过度暴露会导致神经毒性. 这项研究使用脑成像来寻找生物标志物,识别改变的大脑网络,特别是在丘脑,以区分暴露个体和健康对照.
科学领域:
- 神经成像是一种神经成像.
- 神经毒理学 神经毒理学
- 生物标志物发现发现
背景情况:
- 慢性 (Mn) 过度暴露与神经毒性有关,导致运动和认知缺陷.
- 接工人是面临Mn相关神经毒性风险的人群.
- 确定可靠的生物标志物对于早期检测和干预至关重要.
研究的目的:
- 利用基于多变量源的形态测量 (SBM) 来识别大脑结构生物标志物,使Mn暴露的接者与健康的对照者 (HC) 有区别.
- 探索SBM的实用性,以了解职业暴露的神经毒性影响.
主要方法:
- 从45名接触Mn的接工人和33名HC获得3DT1加权的MRI扫描.
- 应用SBM提取灰色物质的结构共变网络.
- 使用线性模型和接收器操作特征 (ROC) 曲线分析来识别区分模式和潜在的生物标志物.
主要成果:
- 五个不同的结构部件在接工和HC之间存在差异.
- 较低的灰色物质负载重量在基底,丘脑,默认模式网络和叶网络中被观察到.
- 在传感器运动网络中发现了更高的负载重量,通过ROC分析,乳头网络显示了最高的分类功率.
结论:
- 暴露于Mn的接工人的大脑结构改变可能是运动控制,认知功能和信息处理的基础.
- 基底,乳头和默认模式网络都与Mn过度暴露有关.
- 这项研究强调SBM作为一种有价值的多变量方法,用于识别Mn暴露的神经生物学标志物.
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