相关实验视频

Updated: Jun 21, 2025

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

在患有帕金森病的患者中,subthalamic核局部场潜在稳定性

Alfonso Fasano¹, Hideo Mure², Genko Oyama³

¹Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Canada; Division of Neurology, University of Toronto, Toronto, Canada; Krembil Brain Institute, University Health Network, Toronto, Canada; Center for Advancing Neurotechnological Innovation to Application, Toronto, Canada.

Neurobiology of disease

|July 5, 2024

概括

随着时间的推移,可以在帕金森病 (PD) 患者中可靠地检测局部场潜力 (LFPs),这些患者具有亚thalamic核深度大脑刺激 (STN-DBS). 在研究访问期间,β和马波段的振荡活动显著增加.

科学领域:

神经科学是一个神经科学.
临床神经学临床神经学
生物医学工程生物医学工程

背景情况:

局部场势 (LFP) 对于理解帕金森病 (PD) 中的振荡活动至关重要.
在PD患者中LFPs的纵向变化接受脑下核深度大脑刺激 (STN-DBS) 的PD患者仍未得到充分探索.
这项研究解决了临床环境中关于LFPs时间演变的知识差距.

研究的目的:

在接受STN-DBS的PD患者中调查LFPs的波动和纵向变化.
通过多次访问,评估LFP记录在现实世界的临床环境中的可靠性.
分析特定的振荡波段 (β和gamma) 的时间变化.

主要方法:

在22名STN-DBS患者中进行了双边LFP记录,这些患者在三次独立访问期间患有PD,刺激被关闭.
每个LFP记录的峰值振幅和频段功率测量被计算出来.
使用统计分析,包括ANOVA和后期测试,来评估随时间的变化.

主要成果:

在所有三次访问中,高比例的患者成功检测到LFP (81.8%至100%).
随着时间的推移,主要峰值振幅没有显著变化.
从第一个访问到随后的访问,检测到第二大峰幅度的显著增加,以及低β,高β和马波段功率.

结论:

在STN-DBS的PD患者中,可以在多次临床访问中可靠地记录LFP.
这项研究为LFP振荡活动的纵向演变提供了宝贵的见解,特别是在β和波段.
这些发现支持LFP监测对了解PD疾病进展和治疗效果的有用性.

关键词:

深度大脑刺激是什么?当地现场潜力当地现场潜力帕金森病的疾病.

更多相关视频

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats

Published on: June 22, 2017

相关概念视频

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...