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相关实验视频

Updated: Jun 21, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

动态超声波定位显微镜,没有心电图门.

Nin Ghigo¹, Gerardo Ramos-Palacios², Chloé Bourquin¹

¹Department of Engineering Physics, Polytechnique Montréal, Montréal, Quebec, Canada.

Ultrasound in medicine & biology

|July 5, 2024

概括

这项研究引入了动态超声波定位显微镜 (DULM) 的运动匹配技术,消除了对心电图门的需求. 这一进步简化了DULM实验,并提高了基于微泡的流速测量的可访问性.

关键词:

大脑的流量大脑的流量.动态超声波定位显微镜学微气泡是一种微气泡.非侵入性跨骨动态脑成像技术冲动性指数是指冲动性的指数.

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Last Updated: Jun 21, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

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Published on: January 7, 2019

High-Speed Ultraviolet Photoacoustic Microscopy for Histological Imaging with Virtual-Staining assisted by Deep Learning

High-Speed Ultraviolet Photoacoustic Microscopy for Histological Imaging with Virtual-Staining assisted by Deep Learning

Published on: April 28, 2022

科学领域:

生物医学工程生物医学工程
医疗成像医学成像
超声波技术超声波技术超声波技术

背景情况:

动态超声波定位显微镜 (DULM) 通过追踪微泡 (MBs) 能够在动物大脑中进行非侵入性脉动性测量.
传统的DULM方法需要ECG-gating,这限制了应用并增加了获取时间.
需要使用不依赖外部同步信号的DULM技术.

研究的目的:

消除了在动态超声波定位显微镜 (DULM) 实验中对心电图门的要求.
在DULM中引入一种新的运动匹配方法,以准确地记录时间.
在不影响数据质量的情况下,在更广泛的数据集上实现DULM.

主要方法:

开发了一个运动匹配算法,利用组织多普勒信号来利用固有的循环脑组织运动.
估计的组织多普勒对组在地方最大的位置在头骨的表面.
通过将其组织多普勒信号与参考组对齐,与心脏周期同步,记录时间的组.

主要成果:

运动匹配方法在老鼠,小鼠 (2D) 和猫 (3D) 模型中成功验证.
运动匹配时间记录的结果与使用ECG-gating获得的结果相似.
证明了动态速度和密度cine-loops的提取和估计的脉动性指数没有心电图数据.

结论:

DULM可以在没有外部门的情况下有效地执行,从而扩大其适用于任何具有足够微泡检测的超声本地化显微镜数据集的应用范围.
动作匹配用于时间记录,通过简化实验程序和增加可访问性,显著提升了DULM.
这种技术增强了DULM在各种动物模型中进行非侵入性血液动力学评估的实用性.