干眼疾病亚型的分类
M Vidal-Rohr1, J P Craig2, L N Davies1
1School of Optometry, College of Health and Life Sciences, Aston University, Birmingham, UK.
概括
这项研究确定了分类干眼病 (DED) 亚型的新临床标准. 在英国人口中,蒸发性DED (EDE) 是最常见的,而缺乏水性的DED (ADDE) 在英国人口中较少.
科学领域:
- 眼科医生 眼科 眼科
- 干眼疾病研究 干眼疾病研究
- 临床流行病学临床流行病学
背景情况:
- 目前干眼病 (DED) 的分类 (水性缺陷 - ADDE,蒸发性 - EDE) 缺乏一致的临床定义.
- 这种不一致性阻碍了对DED亚型的流行病学研究.
研究的目的:
- 为了建立数据驱动的切断值来分类ADDE和EDE.
- 为了使DED亚型的流行病学研究更加一致.
主要方法:
- 招生261名英国居民,代表普通人口.
- 使用TFOS DEWS II标准进行DED诊断.
- 测量了梅博姆腺损失,脂质层厚度 (LLT),撕裂半月体高度 (TMH) 和撕裂蒸发,以表征亚型.
主要成果:
- 蒸发性DED (EDE) 的特点是梅博米腺损失>28%,LLT<3,蒸发>46g/m2/h.
- 缺水性DED (ADDE) 的特点是TMH<0.2毫米.
- 患病率:ADDE 6.2%,EDE 64.2%,两者均为 11.1%,未分类 18.5%. 没有分类. 与ADDE相关的隐形眼镜佩戴和电脑使用;与EDE相关的年龄.
结论:
- 数据驱动的分类证实EDE是最常见的DED亚型.
- 在一个可概括的英国人群中,ADDE单独占了大约16个DED病例中的1个.
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