使用NCBI数据集探索和检索生命树中物种的序列和元数据
Nuala A O'Leary1, Eric Cox2, J Bradley Holmes2
1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD, 20894, USA. olearyna@ncbi.nlm.nih.gov.
Scientific data
|July 5, 2024
概括
NCBI数据集通过提供可扩展的对序列数据的访问来增强生物研究. 该资源遵循FAIR原则,改善了全球科学家的数据可发现性和可用性.
科学领域:
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
- 数据科学数据科学数据科学
背景情况:
- 生物研究需要来自公共存储库的多种类型的数据.
- 越来越多的数据量和复杂性挑战了数据的可发现性和可用性.
- 国家生物技术信息中心 (NCBI) 开发了解决这些问题的方法.
研究的目的:
- 引入NCBI数据库作为获取生物数据的资源.
- 解释NCBI数据集如何解决数据可访问性和可用性方面的挑战.
- 概述通过NCBI数据集提供的数据和访问方法的范围.
主要方法:
- NCBI数据集提供了对生物序列,注释和元数据的访问权限.
- 它遵循FAIR数据管理原则 (可查找,可访问,可互操作,可重复使用).
- 访问是通过Web接口,命令行工具和记录的API来促进的.
主要成果:
- NCBI数据集提供了简单,全面和可扩展的数据访问.
- 数据以序列和元数据的包装形式交付.
- 这有助于改进数据检索,共享,归因和重用.
结论:
- NCBI 数据集使研究人员能够无访问重要的生物信息.
- 该平台提高了数据的可用性,并通过有效的数据共享和归因促进进一步的研究.
- 它代表了管理和访问大型生物数据集的重大进步.
相关概念视频
Evolutionary Relationships through Genome Comparisons
5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
The Tree of Life - Bacteria, Archaea, Eukaryotes
32.3K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
32.3K
Multi-species Conserved Sequences
3.9K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
3.9K
Phylogeny
43.8K
Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
43.8K
Gene Evolution - Fast or Slow?
7.1K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.1K
Phylogenetic Trees
45.3K
Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
45.3K


