昼夜节律,细胞周期和氧化还原节律之间的结合模型揭示了它们对氧化应激的调节
Kosaku Masuda1,2, Takeshi Sakurai3,4,5, Arisa Hirano6,7
1Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan. kosaku.masuda@gmail.com.
Scientific reports
|July 5, 2024
概括
生物体的节律,如昼夜钟,细胞周期和氧化还原节律相互作用. 适度的合将氧化应激和细胞损伤最小化,而强的合则会增加它.
科学领域:
- * * 时间生物学
- * 细胞生物学 细胞生物学
- * 系统生物学 系统生物学
背景情况:
- *有机体有三个主要的生物振荡器:昼夜钟,细胞周期和氧化还原节奏.
- * 这些振荡器是自主但相互作用的,但这些相互作用的好处仍然不清楚.
- *了解这些相互作用对于细胞健康和生物体适应至关重要.
研究的目的:
- * 模拟一个合振荡器系统,以研究生物节奏之间的相互作用的影响.
- * 确定合如何影响细胞对氧化应激反应,特别是M阶段的过氧化 (H2O2) 水平.
- * 探索振荡器同步和自主性在多细胞生物中的作用及其环境适应.
主要方法:
- * 为合生物振荡器 (日间钟,细胞周期,氧化还原节奏) 开发计算模型.
- *模拟不同合强度以分析相位关系和过氧化 (H2O2) 水平.
- *研究多细胞系统,以评估相变对环境同步和适应性的影响.
主要成果:
- *振荡器之间的合可以防止细胞周期M阶段的高H2O2水平.
- * 适度合通过优化相位关系来减少氧化应激和细胞损伤.
- *强的合会提高H2O2水平,增加细胞损伤,并破坏细胞循环.
- * 多细胞模型显示相位变化增强了环境同步,但降低了适应最佳条件的适应性.
结论:
- *振荡器的自主性和同步性对于协调相位关系和最大限度地减少氧化应激至关重要.
- * 合强度根据环境条件动态平衡自主性和同步性.
- * 生物节律之间的优化相位关系是细胞抵抗氧化损伤的关键.
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