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化学性对大脑的作用 - - 关于决策,冲动性和高性欲的神经相关性 (ERP)
Johanna Schwarz1, Marcus Gertzen2, Andrea Rabenstein3
1Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Germany. J.Schwarz@med.uni-muenchen.de.
概括
化学性使用者表现出执行功能受损和抑制控制,其证据是决策过程中N2电生理反应减少. 这些神经生理变化可能会增加药物滥用和过度性行为的风险.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 公共卫生 公共卫生
背景情况:
- 化学性,在与男性发生性关系的男性中普遍存在,涉及使用特定物质来增强性经验.
- 化学性使用与体质,心理和神经系统的并发症有关,包括性传播疾病,抑郁症,冲动控制障碍和过度性行为.
- 执行功能的缺陷和冲动性变化与成,冲动控制障碍和前脑功能障碍有关.
研究的目的:
- 研究化学性使用者抑制和决策的神经生理相关性.
- 使用电脑电图 (EEG) 范式,探索化学性对事件相关潜能 (N2,P3) 的影响.
主要方法:
- 使用了一个听觉的Go/NoGo/自愿选择EEG范式.
- 15名化学性使用者和14名匹配的对照对象 (所有与男性发生性关系的男性) 参加.
- 收集了临床数据,人口统计信息,幸福感和性行为.
主要成果:
- 化学性使用者比非使用者表现出更明显的临床症状,高性欲和性风险行为.
- 两组之间没有观察到P3幅度的显著差异.
- 化学性使用者在决策过程中表现出前中部区域的电生理N2反应下降,这表明执行功能和抑制控制受损.
结论:
- 化学性使用与执行功能受损和抑制性控制有关,由减少的N2反应表明.
- 这些神经生物学障碍可能会导致风险行为增加,包括药物滥用和过度性行为.
- 了解这些机制可以为有针对性的干预提供信息,以减轻负面影响和改善福祉.
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