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Updated: Jun 21, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

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BAP1的和基因组编辑功能性地分类体质和生殖系变异

Andrew J Waters1, Timothy Brendler-Spaeth2, Danielle Smith2

  • 1Wellcome Sanger Institute, Hinxton, UK. aw28@sanger.ac.uk.

Nature genetics
|July 5, 2024
PubMed
概括

研究人员使用基因编辑研究BAP1基因变异,以了解它们与癌症和神经发育的联系. 破坏性变异与更高的IGF-1水平有关,这表明了新的治疗点.

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相关概念视频

RNA Editing02:23

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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