慢性创伤性脑损伤患者定量MR神经成像异常率

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Farzaneh Rahmani¹, Richard D Batson², Alexandra Zimmerman³

¹Department of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.

|July 5, 2024

概括

定量MRI揭示了慢性轻度创伤性脑损伤 (mTBI) 中广泛存在的大脑异常. 像体积测量, perfusion 和光谱等先进的成像技术显示缩,血流减少和代谢变化,有助于评估mTBI.

科学领域:

神经成像是一种神经成像.
放射学放射学是一门学科.
神经学神经学

背景情况:

轻度创伤性脑损伤 (mTBI) 可以导致微妙的,持久的脑损伤,在传统的MRI上是看不到的.
在临床实践中,mTBI的FDA批准的MR神经成像工具未得到充分利用.

研究的目的:

用先进的定量MR神经成像来调查慢性mTBI后续.
为了评估大脑体积,大脑输液,白质微观结构和神经代谢物.

主要方法:

65名患有慢性mTBI的人接受了MR神经成像 (体积测量,PCASL,DTI,MRS).
分析包括左右不对称,大脑血流,白质完整性和大脑代谢物水平.
影像成像是在受伤后的37个月中位数进行的.

主要成果:

所有参与者都表现出叶片缩或心室体积增加.
白色球体和小脑灰质表现出最多的缩和不对称性.
脑部血液流量减少在头和右额头双肩区域被观察到.
异常的神经代谢物水平 (胆,N-乙酸) 是常见的.

结论:

定量核磁共振显示了连续发生的输液损伤,广泛的缩,不对称性和慢性mTBI中的代谢变化.
体积测量,PCASL和MRS提供了超越DTI的补充洞察力,用于评估慢性mTBI.
这些发现突出了mTBI微妙而持久的脑损伤的敏感标记.

关键词:

扩散张力成像扩散张力成像磁共振光谱学磁共振光谱学伪连续的动脉旋转标签创伤性脑损伤创伤性脑损伤

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