在美国成年人中,生命的基本8和与代谢功能障碍相关的脂肪性肝病之间的关联
Zheng Wang1, Bohan Huang1, Yixuan Ding1
1Department of General Surgery, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
概括
通过Life's Essential 8 (LE8) 测量较高的心血管健康评分与与代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险降低有关. 保持理想的健康行为和因素是预防MASLD的关键.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种普遍存在的慢性肝病.
- MASLD越来越被认为是心血管疾病 (CVD) 的危险因素.
- 通过全面的指标来评估心血管健康 (CVH),例如生活必需品8 (LE8),可以提供有关MASLD风险的见解.
研究的目的:
- 为了研究生命的基本8 (LE8) 分数和MASLD的流行率之间的联系.
- 确定LE8的组成部分,包括健康行为和健康因素得分,是否与MASLD有关.
- 探索LE8-MASLD关系中的潜在人口变化.
主要方法:
- 利用了2017-2020年国家健康和营养检查调查 (NHANES) 的数据.
- 使用最新标准诊断MASLD,并根据美国心脏协会的定义计算LE8分数.
- 采用多变量逻辑回归和受限立方支线模型来分析关联,调整混因素.
主要成果:
- 总共有5646名参与者被分析,其中46.33%被诊断为MASLD.
- 较高的LE8得分显示出与MASLD患病率 (OR=0.19) 有显著的反向关联.
- 无论是LE8健康因子和健康行为得分,都与较低的MASLD风险独立相关.
结论:
- 升高的LE8得分,包括健康因素和行为,与美国成年人中MASLD的流行率降低有显著的关联.
- 具有最佳心血管健康指标的个人不太可能患上MASLD.
- 促进健康生活方式因素和行为的公共卫生倡议对于预防MASLD至关重要.
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