在患有恶性瘤的患者中,素的预后意义 (NIHR健康信息协作TROP-MALIGNANCY研究)
Nathan A Samuel1,2, Alistair Roddick1,2, Ben Glampson1
1NIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, London, U.K.
Cardio-oncology (London, England)
|July 5, 2024
概括
在癌症患者中,心脏中高水平的托罗邦素预测死亡率更高. 这种风险随着热素水平超过正常的上限而增加,无论癌症类型如何.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 生物标志物 生物标志物
背景情况:
- 在患有恶性瘤的患者中,心脏托波素经常升高.
- 这种人群中高位激素的预后值仍然不清楚.
研究的目的:
- 在一大群癌症患者中,研究心脏托罗邦素水平与死亡率之间的关联.
- 为了确定热素的预后意义是否在固体瘤和血液恶性瘤之间有所不同.
主要方法:
- 利用了来自国家卫生研究院 (NIHR) 健康信息协作团队的数据.
- 在5个英国中心 (2010-2017年) 分析了5571名患有原发性恶性瘤诊断的患者的类素水平.
- 与实验室的99百分位上限正常值 (xULN) 相对的标准化峰值托罗邦水平.
主要成果:
- 在所有恶性瘤患者 (HR 2.01) 和固体瘤 (HR 1.84) 和血性恶性瘤 (HR 2.72) 亚组中,增加的托波是死亡的独立预测因子.
- 在越来越多的托洛类别中观察到死亡风险增加的显著趋势 (p < 0.001).
- 死亡风险在正常的上限以下保持稳定,但在正常的上限以上大幅增加.
结论:
- 心脏热素升高与癌症患者的死亡率增加显著相关,无论癌症亚型如何.
- 当水平超过ULN时,热素的预后影响最为明显.
- 这一发现甚至在没有急性冠状动脉综合征的情况下也是如此.
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