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在下部胃肠道出血中对血输血的特兰胺酸的影响-双盲前性随机对照试验
Avihai Moscovici1,2, Ahmad Nasasra1,2, Jonathan Hammerschlag1,2
1Department of Surgery, Shamir Medical Center, Beer Yaacov, Israel.
World journal of surgery
|July 6, 2024
概括
特兰胺酸 (TXA) 并没有显著减少急性下胃肠道出血的患者输血的需要. 这项研究发现,在TXA和安慰剂组之间,包装红细胞 (PRBC) 输血要求没有差异.
科学领域:
- 胃肠病学 胃肠病学
- 血液学 血液学 血液学
- 紧急医疗 紧急医疗
背景情况:
- 急性胃肠道出血是经常出现的医疗紧急情况.
- 胺酸 (TXA) 是一种抗纤维解质剂,可以抑制等离子体,减少血块分解.
- 以前的研究表明,TXA在减少对创伤,手术和上部肠道出血的输血方面的有效性.
研究的目的:
- 评估静脉注射TXA在治疗急性下胃肠道出血方面的有效性.
- 为了确定TXA是否减少了患有下肠道出血的患者的输血需求.
主要方法:
- 一个单中心,双盲,前性研究招募了81名18岁以上的患者,他们有活跃的下部肠道出血和贫血.
- 患者在结肠镜检查之前接受了静脉TXA或安慰剂.
- 测量的主要结果是需要输血红细胞 (PRBC) 输血以及输血单位数量.
主要成果:
- 81名患者被随机分配:39名接受TXA,42名接受安慰剂.
- 在TXA组 (21名患者) 和安慰剂组 (22名患者) 之间没有观察到PRBC输血率的显著差异.
- 同样,在TXA (14名患者) 和安慰剂 (15名患者) 组之间,对两个或更多PRBC单元的需求没有显著差异.
结论:
- 静脉注射TXA对急性下胃肠道出血患者的输血需求没有显著影响.
- 该研究得出的结论是,TXA似乎不会显著影响这个患者群体中PRBC输血需求.
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