肺功能与老年人的大脑衰老和认知转变有关:基于人口的队列研究
Giulia Grande1,2, Yuanjing Li1, Caterina Trevisan1,3
1Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
概括
肺功能不佳,以低峰呼气流 (PEF) 表示,显著增加痴呆和认知障碍的风险. 这种下降可能与加速的大脑缩和微血管损伤有关.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 老年学是一门学科.
背景情况:
- 研究老年人肺功能和认知衰退之间的联系.
- 检查峰值呼气流 (PEF) 作为痴呆症和认知障碍没有痴呆症 (CIND) 的预测因素.
研究的目的:
- 为了确定峰值呼气流 (PEF) 与痴呆症,CIND和CIND进展到痴呆症的关联.
- 探索潜在的神经病理机制,将不良的肺功能与认知障碍联系起来.
主要方法:
- 这是一项为期15年,针对60岁以上的成年人进行的基于人口的队列研究.
- 使用既定标准和认知电池评估痴呆症,CIND和进展.
- 在一个亚样本中利用脑部MRI来分析神经退行和小血管疾病标志物.
主要成果:
- 较低的PEF (<第10百分位) 与痴呆症 (HR=1.89) 和CIND (HR=1.55) 的风险增加有关.
- 较差的PEF与更快的腹腔扩大相关 (β=0.67毫升/年) 和更高的发展缺口的几率 (OR=5.05).
- 随着PEF差 (HR=2.44),观察到CIND进展为痴呆的风险增加的趋势,尽管在统计学上不显著.
结论:
- 通过PEF测量的肺功能减弱是发展痴呆症和认知障碍的重要危险因素.
- 肺功能不良可能通过涉及大脑缩和微血管损伤的机制加速认知衰退.
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